Drug interactions
Dihydroergotamine + Haloperidol
Severity: Moderate
Dihydroergotamine and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic and dopaminergic activity, and combining it with an antipsychotic raises theoretical concerns of serotonin toxicity or neuroleptic malignant syndrome. Documented cases are rare. Dihydroergotamine is also a CYP3A4 substrate, but haloperidol is not a significant inhibitor.
What this interaction means in plain words
Dihydroergotamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Haloperidol belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and dopaminergic modulation; not firmly established.
What to do
Monitor for mental status change, autonomic instability, hyperthermia and rigidity when used together.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Haloperidol?
MediHelp rates the interaction as moderate. Dihydroergotamine and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine has serotonergic and dopaminergic activity, and combining it with an antipsychotic raises theoretical concerns of serotonin toxicity or neuroleptic malignant syndrome. Documented cases are rare. Dihydroergotamine is also a CYP3A4 substrate, but haloperidol is not a significant inhibitor.
How serious is the interaction between Dihydroergotamine and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, autonomic instability, hyperthermia and rigidity when used together.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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