Drug interactions
Dihydroergotamine + Labetalol
Severity: Moderate
Dihydroergotamine and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine causes peripheral vasoconstriction, and beta blockade may leave this unopposed, potentially worsening peripheral ischemia or vasospasm. The effect is mainly of concern with higher or repeated doses of ergot.
What this interaction means in plain words
Dihydroergotamine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Labetalol belongs to Cardiovascular.
Why it happens
Ergot-induced vasoconstriction combined with beta-blockade that reduces beta-2 mediated vasodilation.
What to do
Monitor for cold extremities, numbness, color change or chest pain. Stop dihydroergotamine and seek urgent review if signs of ischemia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Labetalol?
MediHelp rates the interaction as moderate. Dihydroergotamine and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine causes peripheral vasoconstriction, and beta blockade may leave this unopposed, potentially worsening peripheral ischemia or vasospasm. The effect is mainly of concern with higher or repeated doses of ergot.
How serious is the interaction between Dihydroergotamine and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for cold extremities, numbness, color change or chest pain. Stop dihydroergotamine and seek urgent review if signs of ischemia appear.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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