Drug interactions
Dihydroergotamine + Lurasidone
Severity: Moderate
Dihydroergotamine and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lurasidone is a CYP3A4 substrate, and dihydroergotamine is a serotonergic agent that may theoretically contribute to serotonin toxicity with antipsychotics. The clinical significance is uncertain, and the legacy concern about neuroleptic malignant syndrome is theoretical. Dihydroergotamine also causes vasoconstriction and may add to adverse effects in vulnerable patients.
What this interaction means in plain words
Dihydroergotamine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Lurasidone belongs to Central Nervous System.
Why it happens
Theoretical additive serotonergic and dopaminergic effects; the mechanism is not firmly established.
What to do
Monitor for agitation, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity when the two are used together. Review other serotonergic drugs and CYP3A4 inhibitors the patient takes, since these raise dihydroergotamine toxicity risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Lurasidone?
MediHelp rates the interaction as moderate. Dihydroergotamine and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lurasidone is a CYP3A4 substrate, and dihydroergotamine is a serotonergic agent that may theoretically contribute to serotonin toxicity with antipsychotics. The clinical significance is uncertain, and the legacy concern about neuroleptic malignant syndrome is theoretical. Dihydroergotamine also causes vasoconstriction and may add to adverse effects in vulnerable patients.
How serious is the interaction between Dihydroergotamine and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, autonomic instability, hyperthermia, rigidity and neuromuscular hyperactivity when the two are used together. Review other serotonergic drugs and CYP3A4 inhibitors the patient takes, since these raise dihydroergotamine toxicity risk.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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