Drug interactions
Dihydroergotamine + Pentazocine
Severity: Minor
Dihydroergotamine and Pentazocine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic receptor activity, and pentazocine has rarely been associated with serotonin toxicity. The combination could theoretically add to serotonergic effects, although clinical evidence is scant. Dihydroergotamine is also vulnerable to CYP3A4 inhibitors, not relevant to pentazocine here.
What this interaction means in plain words
Dihydroergotamine and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dihydroergotamine belongs to Central Nervous System; Pentazocine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic effects via 5-HT receptor agonism; the mechanism is not firmly established.
What to do
No routine change is needed; counsel the patient to report agitation, tremor, sweating or fever.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pentazocine
- Calcium / magnesium / potassium / sodium oxybates + Pentazocine Contraindicated
- Olanzapine / samidorphan + Pentazocine Contraindicated
- Pentazocine + Phenelzine Contraindicated
- Pentazocine + Tranylcypromine Contraindicated
- Alfentanil + Pentazocine Major
- Alprazolam + Pentazocine Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Pentazocine?
MediHelp rates the interaction as minor. Dihydroergotamine and Pentazocine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dihydroergotamine has serotonergic receptor activity, and pentazocine has rarely been associated with serotonin toxicity. The combination could theoretically add to serotonergic effects, although clinical evidence is scant. Dihydroergotamine is also vulnerable to CYP3A4 inhibitors, not relevant to pentazocine here.
How serious is the interaction between Dihydroergotamine and Pentazocine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to report agitation, tremor, sweating or fever.
What other medicines interact with Pentazocine?
MediHelp also lists interactions of Pentazocine with, for example, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan, Phenelzine. The full list is on the Pentazocine page.
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