Drug interactions
Dihydroergotamine + Perphenazine
Severity: Moderate
Dihydroergotamine and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dihydroergotamine has serotonergic activity and can cause vasoconstriction, while perphenazine blocks dopamine and serotonin receptors. Rare serotonin toxicity or neuroleptic malignant syndrome features have been proposed with such combinations, though evidence is limited.
What this interaction means in plain words
Dihydroergotamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dihydroergotamine belongs to Central Nervous System; Perphenazine belongs to Central Nervous System.
Why it happens
Overlapping serotonergic and dopaminergic receptor effects; the interaction is largely theoretical.
What to do
Monitor for mental status change, hyperthermia, rigidity and autonomic instability when using both agents. Stop the combination if these features develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dihydroergotamine with Perphenazine?
MediHelp rates the interaction as moderate. Dihydroergotamine and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dihydroergotamine has serotonergic activity and can cause vasoconstriction, while perphenazine blocks dopamine and serotonin receptors. Rare serotonin toxicity or neuroleptic malignant syndrome features have been proposed with such combinations, though evidence is limited.
How serious is the interaction between Dihydroergotamine and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for mental status change, hyperthermia, rigidity and autonomic instability when using both agents. Stop the combination if these features develop.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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