Drug interactions
Dipyridamole + Porfimer
Severity: Moderate
Dipyridamole and Porfimer: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Photodynamic therapy with porfimer depends on light-activated generation of reactive oxygen species and consequent vascular occlusion in tissue. Dipyridamole, a vasodilator and antithrombotic, could reduce this thrombotic effect and lower efficacy. Evidence is limited to labeling-level cautions.
What this interaction means in plain words
Dipyridamole and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dipyridamole belongs to Cardiovascular; Porfimer belongs to Miscellaneous.
Why it happens
Dipyridamole's antithrombotic and vasodilating effects may counteract the vascular occlusion and thromboxane-mediated tissue damage needed for porfimer's photodynamic effect.
What to do
Consider whether dipyridamole can be held around photodynamic therapy; if not, monitor tumor response closely.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dipyridamole
- Dipyridamole + Riociguat Contraindicated
- Adenosine + Dipyridamole Major
- Betrixaban + Dipyridamole Major
- Dabigatran + Dipyridamole Major
- Dipyridamole + Regadenoson Major
- Dipyridamole + Venetoclax Major
Other interactions of Porfimer
Frequently asked questions
Can I take Dipyridamole with Porfimer?
MediHelp rates the interaction as moderate. Dipyridamole and Porfimer can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Photodynamic therapy with porfimer depends on light-activated generation of reactive oxygen species and consequent vascular occlusion in tissue. Dipyridamole, a vasodilator and antithrombotic, could reduce this thrombotic effect and lower efficacy. Evidence is limited to labeling-level cautions.
How serious is the interaction between Dipyridamole and Porfimer?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider whether dipyridamole can be held around photodynamic therapy; if not, monitor tumor response closely.
What other medicines interact with Dipyridamole?
MediHelp also lists interactions of Dipyridamole with, for example, Riociguat, Adenosine, Betrixaban. The full list is on the Dipyridamole page.
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