Drug interactions
Disopyramide + Fluoxetine
Severity: Major
Disopyramide and Fluoxetine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and can cause torsades de pointes. Fluoxetine may add to this risk. Fluoxetine inhibits CYP2D6 and may also modestly alter disopyramide handling, and disopyramide adds anticholinergic effects.
What this interaction means in plain words
Disopyramide and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Fluoxetine belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with possible pharmacokinetic effects of fluoxetine on disopyramide.
What to do
Avoid if possible, and consider an antidepressant with lower QT risk. If used together, monitor ECG and electrolytes and watch for anticholinergic effects and arrhythmia.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Fluoxetine?
MediHelp rates the interaction as major. Disopyramide and Fluoxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide prolongs the QT interval and can cause torsades de pointes. Fluoxetine may add to this risk. Fluoxetine inhibits CYP2D6 and may also modestly alter disopyramide handling, and disopyramide adds anticholinergic effects.
How serious is the interaction between Disopyramide and Fluoxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, and consider an antidepressant with lower QT risk. If used together, monitor ECG and electrolytes and watch for anticholinergic effects and arrhythmia.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
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