Drug interactions
Disopyramide + Formoterol-mometasone
Severity: Major
Disopyramide and Formoterol-mometasone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic with a clear risk of QT prolongation and torsades de pointes. Formoterol can add to QT lengthening and may lower potassium, which increases the risk of arrhythmia.
What this interaction means in plain words
Disopyramide and Formoterol-mometasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Formoterol-mometasone belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-2 agonist induced hypokalemia increasing proarrhythmic susceptibility.
What to do
Avoid the combination where possible. If both are required, monitor ECG and keep potassium and magnesium within normal range.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Formoterol-mometasone
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Formoterol-mometasone?
MediHelp rates the interaction as major. Disopyramide and Formoterol-mometasone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is a class Ia antiarrhythmic with a clear risk of QT prolongation and torsades de pointes. Formoterol can add to QT lengthening and may lower potassium, which increases the risk of arrhythmia.
How serious is the interaction between Disopyramide and Formoterol-mometasone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, monitor ECG and keep potassium and magnesium within normal range.
What other medicines interact with Formoterol-mometasone?
MediHelp also lists interactions of Formoterol-mometasone with, for example, Amiodarone, Amisulpride, Amoxapine. The full list is on the Formoterol-mometasone page.
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