Drug interactions
Disopyramide + Ipratropium-salbutamol
Severity: Moderate
Disopyramide and Ipratropium-salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and can cause torsades de pointes. High-dose salbutamol can cause tachycardia, hypokalemia and some QT lengthening, which may raise arrhythmia risk. Disopyramide also has anticholinergic effects additive to ipratropium.
What this interaction means in plain words
Disopyramide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Disopyramide belongs to Cardiovascular; Ipratropium-salbutamol belongs to Respiratory.
Why it happens
Additive QT prolongation, with beta-agonist-induced hypokalemia increasing proarrhythmic risk; additive anticholinergic effects.
What to do
Check potassium and magnesium and consider ECG monitoring, especially with frequent or high-dose salbutamol. Correct electrolyte abnormalities and watch for anticholinergic effects such as urinary retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ipratropium-salbutamol
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Ipratropium-salbutamol?
MediHelp rates the interaction as moderate. Disopyramide and Ipratropium-salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Disopyramide prolongs the QT interval and can cause torsades de pointes. High-dose salbutamol can cause tachycardia, hypokalemia and some QT lengthening, which may raise arrhythmia risk. Disopyramide also has anticholinergic effects additive to ipratropium.
How serious is the interaction between Disopyramide and Ipratropium-salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium and consider ECG monitoring, especially with frequent or high-dose salbutamol. Correct electrolyte abnormalities and watch for anticholinergic effects such as urinary retention.
What other medicines interact with Ipratropium-salbutamol?
MediHelp also lists interactions of Ipratropium-salbutamol with, for example, Amisulpride, Arsenic trioxide, Carvedilol. The full list is on the Ipratropium-salbutamol page.
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