Drug interactions
Disopyramide + Levofloxacin
Severity: Major
Disopyramide and Levofloxacin: major interaction.
Last updated Sources: EMA SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and combining them raises the risk of torsades de pointes and other ventricular arrhythmias. Disopyramide also carries intrinsic proarrhythmic risk, so the additive effect is clinically significant.
What this interaction means in plain words
Disopyramide and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Levofloxacin belongs to Anti Bacterial.
Why it happens
Additive QT prolongation through blockade of cardiac potassium channels (hERG).
What to do
Avoid the combination where possible and choose a non-QT-prolonging antibiotic. If unavoidable, correct potassium and magnesium and monitor ECG for QTc prolongation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Levofloxacin?
MediHelp rates the interaction as major. Disopyramide and Levofloxacin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and combining them raises the risk of torsades de pointes and other ventricular arrhythmias. Disopyramide also carries intrinsic proarrhythmic risk, so the additive effect is clinically significant.
How serious is the interaction between Disopyramide and Levofloxacin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose a non-QT-prolonging antibiotic. If unavoidable, correct potassium and magnesium and monitor ECG for QTc prolongation.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
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