Drug interactions
Disopyramide + Mifepristone
Severity: Major
Disopyramide and Mifepristone: major interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is partly metabolized by CYP3A4 and can prolong the QT interval. Mifepristone inhibition raises disopyramide levels and adds its own QT effect, increasing the risk of torsades de pointes.
What this interaction means in plain words
Disopyramide and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Mifepristone belongs to Endocrine.
Why it happens
CYP3A4 inhibition by mifepristone plus additive QT prolongation.
What to do
Avoid the combination where possible. If it is necessary, monitor ECG/QTc and serum disopyramide levels and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Mifepristone?
MediHelp rates the interaction as major. Disopyramide and Mifepristone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide is partly metabolized by CYP3A4 and can prolong the QT interval. Mifepristone inhibition raises disopyramide levels and adds its own QT effect, increasing the risk of torsades de pointes.
How serious is the interaction between Disopyramide and Mifepristone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If it is necessary, monitor ECG/QTc and serum disopyramide levels and correct electrolytes.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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