Drug interactions
Disopyramide + Quetiapine
Severity: Major
Disopyramide and Quetiapine: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and combined use raises the risk of torsades de pointes, particularly with electrolyte disturbances, bradycardia or structural heart disease. Disopyramide is a class Ia antiarrhythmic with a well-established proarrhythmic risk.
What this interaction means in plain words
Disopyramide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Quetiapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarization through potassium channel blockade.
What to do
Avoid the combination if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor QTc. Consider an alternative antipsychotic with lower QT liability.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Biquelle XL 150mg prolonged-release tablets - SmPC sections 4.3/4.5 (class statement: medicinal products known to cause electrolyte imbalance or to increase QT interval; "Caution should be exercised when quetiapine is used concomitantly with medicinal products known to cause electrolyte imbalance o… — electronic medicines compendium (UK SmPC)
Other interactions of Quetiapine
- Adagrasib + Quetiapine Major
- Amiodarone + Quetiapine Major
- Amisulpride + Quetiapine Major
- Amoxapine + Quetiapine Major
- Anagrelide + Quetiapine Major
- Apalutamide + Quetiapine Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Quetiapine?
MediHelp rates the interaction as major. Disopyramide and Quetiapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and combined use raises the risk of torsades de pointes, particularly with electrolyte disturbances, bradycardia or structural heart disease. Disopyramide is a class Ia antiarrhythmic with a well-established proarrhythmic risk.
How serious is the interaction between Disopyramide and Quetiapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise obtain a baseline ECG, correct potassium and magnesium, and monitor QTc. Consider an alternative antipsychotic with lower QT liability.
What other medicines interact with Quetiapine?
MediHelp also lists interactions of Quetiapine with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Quetiapine page.
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