Drug interactions
Disopyramide + Umeclidinium-vilanterol
Severity: Major
Disopyramide and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide prolongs the QT interval and has anticholinergic activity of its own. Vilanterol may add to cardiac stimulation and hypokalemia risk, and umeclidinium adds to the anticholinergic burden, which increases arrhythmia risk and antimuscarinic adverse effects.
What this interaction means in plain words
Disopyramide and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Umeclidinium-vilanterol belongs to Respiratory.
Why it happens
Additive QT prolongation and beta-adrenergic cardiac effects, plus additive antimuscarinic activity.
What to do
Monitor ECG and serum potassium, and consider an alternative antiarrhythmic if the QTc lengthens. Watch for urinary retention and dry mouth from the combined anticholinergic effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Disopyramide and Umeclidinium-vilanterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Umeclidinium-vilanterol
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Disopyramide and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Disopyramide prolongs the QT interval and has anticholinergic activity of its own. Vilanterol may add to cardiac stimulation and hypokalemia risk, and umeclidinium adds to the anticholinergic burden, which increases arrhythmia risk and antimuscarinic adverse effects.
How serious is the interaction between Disopyramide and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and serum potassium, and consider an alternative antiarrhythmic if the QTc lengthens. Watch for urinary retention and dry mouth from the combined anticholinergic effects.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
