Drug interactions
Disopyramide + Verapamil
Severity: Major
Disopyramide and Verapamil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs depress cardiac contractility and conduction, so combined use can precipitate heart failure, hypotension, bradycardia or AV block. Verapamil may also raise disopyramide levels.
What this interaction means in plain words
Disopyramide and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Disopyramide belongs to Cardiovascular; Verapamil belongs to Cardiovascular.
Why it happens
Additive negative inotropic and conduction effects, with possible CYP3A4-mediated reduction of disopyramide clearance by verapamil.
What to do
Avoid the combination where possible. If both are required, follow labeled dosing separation intervals and monitor ECG, blood pressure and signs of heart failure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Verapamil?
MediHelp rates the interaction as major. Disopyramide and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs depress cardiac contractility and conduction, so combined use can precipitate heart failure, hypotension, bradycardia or AV block. Verapamil may also raise disopyramide levels.
How serious is the interaction between Disopyramide and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If both are required, follow labeled dosing separation intervals and monitor ECG, blood pressure and signs of heart failure closely.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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