Drug interactions
Disopyramide + Ziprasidone
Severity: Contraindicated
Disopyramide and Ziprasidone: contraindicated interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disopyramide is a class Ia antiarrhythmic that lengthens the QT interval and can cause torsades de pointes. Adding ziprasidone, which also prolongs QT, increases the chance of serious ventricular arrhythmia and sudden death. Ziprasidone labeling contraindicates use with class Ia antiarrhythmics.
What this interaction means in plain words
Disopyramide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Disopyramide belongs to Cardiovascular; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive blockade of cardiac potassium channels causing delayed repolarization and QT prolongation.
What to do
Avoid the combination and select an alternative antipsychotic or antiarrhythmic with less QT effect. Do not rely on ECG monitoring to make the pairing safe.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Other interactions of Disopyramide
- Amisulpride + Disopyramide Contraindicated
- Desipramine + Disopyramide Contraindicated
- Disopyramide + Dronedarone Contraindicated
- Disopyramide + Itraconazole Contraindicated
- Disopyramide + Ketoconazole Contraindicated
- Disopyramide + Maprotiline Contraindicated
Frequently asked questions
Can I take Disopyramide with Ziprasidone?
MediHelp rates the interaction as contraindicated. Disopyramide and Ziprasidone are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Disopyramide is a class Ia antiarrhythmic that lengthens the QT interval and can cause torsades de pointes. Adding ziprasidone, which also prolongs QT, increases the chance of serious ventricular arrhythmia and sudden death. Ziprasidone labeling contraindicates use with class Ia antiarrhythmics.
How serious is the interaction between Disopyramide and Ziprasidone?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select an alternative antipsychotic or antiarrhythmic with less QT effect. Do not rely on ECG monitoring to make the pairing safe.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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