Drug interactions
Dobutamine + Solriamfetol
Severity: Moderate
Dobutamine and Solriamfetol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Combined with dobutamine, a catecholamine inotrope, cardiovascular stimulation may be additive and cause hypertension, tachycardia or arrhythmia.
What this interaction means in plain words
Dobutamine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dobutamine belongs to Cardiovascular; Solriamfetol belongs to Central Nervous System.
Why it happens
Additive sympathomimetic pharmacodynamic effects on blood pressure and heart rate.
What to do
Monitor blood pressure, heart rate and rhythm continuously while dobutamine is infused in a patient taking solriamfetol. Titrate dobutamine to the lowest effective rate and reduce it if hypertension or tachyarrhythmia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dobutamine
Other interactions of Solriamfetol
- Isocarboxazid + Solriamfetol Contraindicated
- Linezolid + Solriamfetol Contraindicated
- Phenelzine + Solriamfetol Contraindicated
- Procarbazine + Solriamfetol Contraindicated
- Rasagiline + Solriamfetol Contraindicated
- Safinamide + Solriamfetol Contraindicated
Frequently asked questions
Can I take Dobutamine with Solriamfetol?
MediHelp rates the interaction as moderate. Dobutamine and Solriamfetol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solriamfetol is a dopamine and norepinephrine reuptake inhibitor that raises blood pressure and heart rate. Combined with dobutamine, a catecholamine inotrope, cardiovascular stimulation may be additive and cause hypertension, tachycardia or arrhythmia.
How serious is the interaction between Dobutamine and Solriamfetol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and rhythm continuously while dobutamine is infused in a patient taking solriamfetol. Titrate dobutamine to the lowest effective rate and reduce it if hypertension or tachyarrhythmia develops.
What other medicines interact with Dobutamine?
MediHelp also lists interactions of Dobutamine with, for example, Budesonide-formoterol, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Dobutamine page.
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