Drug interactions
Dofetilide + Empagliflozin-metformin
Severity: Moderate
Dofetilide and Empagliflozin-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is a cationic drug that competes for renal tubular secretion and may increase metformin exposure. The effect is generally modest but could matter in renal impairment.
What this interaction means in plain words
Dofetilide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Empagliflozin-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transport (OCT2/MATE) reduces metformin clearance.
What to do
Monitor renal function and metformin tolerability; reduce metformin dose if signs of accumulation appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Empagliflozin-metformin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Empagliflozin-metformin?
MediHelp rates the interaction as moderate. Dofetilide and Empagliflozin-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide is a cationic drug that competes for renal tubular secretion and may increase metformin exposure. The effect is generally modest but could matter in renal impairment.
How serious is the interaction between Dofetilide and Empagliflozin-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and metformin tolerability; reduce metformin dose if signs of accumulation appear.
What other medicines interact with Empagliflozin-metformin?
MediHelp also lists interactions of Empagliflozin-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Empagliflozin-metformin page.
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