Drug interactions
Dofetilide + Eribulin
Severity: Major
Dofetilide and Eribulin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is a potent QT-prolonging antiarrhythmic with a high risk of torsades de pointes. Eribulin can also prolong the QT interval, making serious ventricular arrhythmia more likely.
What this interaction means in plain words
Dofetilide and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Eribulin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation; dofetilide blocks the IKr potassium current.
What to do
Avoid the combination and choose another rhythm-control strategy. If eribulin is essential, continuous ECG monitoring and electrolyte correction are needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Eribulin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Eribulin?
MediHelp rates the interaction as major. Dofetilide and Eribulin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide is a potent QT-prolonging antiarrhythmic with a high risk of torsades de pointes. Eribulin can also prolong the QT interval, making serious ventricular arrhythmia more likely.
How serious is the interaction between Dofetilide and Eribulin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another rhythm-control strategy. If eribulin is essential, continuous ECG monitoring and electrolyte correction are needed.
What other medicines interact with Eribulin?
MediHelp also lists interactions of Eribulin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Eribulin page.
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