Drug interactions
Dofetilide + Glipizide-metformin
Severity: Moderate
Dofetilide and Glipizide-metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide and metformin are both cationic drugs eliminated by renal tubular secretion, so they may compete for clearance. Metformin exposure could rise, increasing the risk of lactic acidosis, and the effect on dofetilide is a concern as well.
What this interaction means in plain words
Dofetilide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Glipizide-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transport (OCT2/MATE) may reduce clearance of metformin and potentially dofetilide.
What to do
Monitor renal function and watch for metformin toxicity and for dofetilide QT prolongation. Consider metformin dose reduction if renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Glipizide-metformin?
MediHelp rates the interaction as moderate. Dofetilide and Glipizide-metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide and metformin are both cationic drugs eliminated by renal tubular secretion, so they may compete for clearance. Metformin exposure could rise, increasing the risk of lactic acidosis, and the effect on dofetilide is a concern as well.
How serious is the interaction between Dofetilide and Glipizide-metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for metformin toxicity and for dofetilide QT prolongation. Consider metformin dose reduction if renal function is impaired.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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