Drug interactions
Dofetilide + Glyburide-metformin
Severity: Minor
Dofetilide and Glyburide-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide is secreted by renal tubular cation transport and may compete with metformin for this route, modestly raising metformin exposure. The clinical significance is generally small at usual doses, but is more relevant in renal impairment.
What this interaction means in plain words
Dofetilide and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dofetilide belongs to Cardiovascular; Glyburide-metformin belongs to Endocrine.
Why it happens
Competition for renal tubular cationic secretion (OCT2/MATE transporters) may reduce metformin clearance.
What to do
Monitor renal function and watch for metformin adverse effects such as gastrointestinal intolerance or lactic acidosis in patients with reduced renal function. No routine dose change is required.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Glyburide-metformin?
MediHelp rates the interaction as minor. Dofetilide and Glyburide-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dofetilide is secreted by renal tubular cation transport and may compete with metformin for this route, modestly raising metformin exposure. The clinical significance is generally small at usual doses, but is more relevant in renal impairment.
How serious is the interaction between Dofetilide and Glyburide-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and watch for metformin adverse effects such as gastrointestinal intolerance or lactic acidosis in patients with reduced renal function. No routine dose change is required.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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