Drug interactions
Dofetilide + Isoflurane
Severity: Major
Dofetilide and Isoflurane: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide markedly prolongs the QT interval and carries a high risk of torsades de pointes. Isoflurane may add to repolarization delay during anesthesia.
What this interaction means in plain words
Dofetilide and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Isoflurane belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Review the dofetilide plan with the anesthesia and cardiology teams and ensure normal potassium and magnesium. Monitor the ECG continuously and have defibrillation and magnesium available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Isoflurane
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Isoflurane?
MediHelp rates the interaction as major. Dofetilide and Isoflurane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide markedly prolongs the QT interval and carries a high risk of torsades de pointes. Isoflurane may add to repolarization delay during anesthesia.
How serious is the interaction between Dofetilide and Isoflurane?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the dofetilide plan with the anesthesia and cardiology teams and ensure normal potassium and magnesium. Monitor the ECG continuously and have defibrillation and magnesium available.
What other medicines interact with Isoflurane?
MediHelp also lists interactions of Isoflurane with, for example, Adrenaline-articaine, Amisulpride, Arsenic trioxide. The full list is on the Isoflurane page.
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