Drug interactions
Dofetilide + Lidocaine
Severity: Moderate
Dofetilide and Lidocaine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide prolongs the QT interval and carries a risk of torsades de pointes. Systemic lidocaine has little QT effect and is not a known contraindication, so the risk is mainly the baseline risk of dofetilide. The legacy contraindication is not well supported for lidocaine.
What this interaction means in plain words
Dofetilide and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Lidocaine belongs to Cardiovascular.
Why it happens
Possible additive cardiac electrophysiologic effects; lidocaine does not meaningfully prolong QT or inhibit dofetilide elimination.
What to do
Monitor ECG and QTc and keep potassium and magnesium within normal range when systemic lidocaine is used in a patient on dofetilide. Local or dental lidocaine requires no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lidocaine
- Bupivacaine liposome + Lidocaine Major
- Disopyramide + Lidocaine Major
- Ex vivo expanded autologous human corneal epithelial cells containing stem cells + Lidocaine Major
- Lidocaine + Nirmatrelvir / ritonavir Major
- Lidocaine + Ombitasvir / paritaprevir / ritonavir and dasabuvir Major
- Lidocaine + Pimozide Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Lidocaine?
MediHelp rates the interaction as moderate. Dofetilide and Lidocaine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide prolongs the QT interval and carries a risk of torsades de pointes. Systemic lidocaine has little QT effect and is not a known contraindication, so the risk is mainly the baseline risk of dofetilide. The legacy contraindication is not well supported for lidocaine.
How serious is the interaction between Dofetilide and Lidocaine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and QTc and keep potassium and magnesium within normal range when systemic lidocaine is used in a patient on dofetilide. Local or dental lidocaine requires no change.
What other medicines interact with Lidocaine?
MediHelp also lists interactions of Lidocaine with, for example, Bupivacaine liposome, Disopyramide, Ex vivo expanded autologous human corneal epithelial cells containing stem cells. The full list is on the Lidocaine page.
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