Drug interactions
Dofetilide + Metformin-repaglinide
Severity: Moderate
Dofetilide and Metformin-repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide and metformin are both cationic drugs handled by renal tubular secretion, so they may compete for elimination. This could raise metformin concentrations, but the clinical significance is modest.
What this interaction means in plain words
Dofetilide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dofetilide belongs to Cardiovascular; Metformin-repaglinide belongs to Endocrine.
Why it happens
Competition for renal tubular cationic transport (OCT2/MATE) between dofetilide and metformin.
What to do
Monitor renal function and for signs of metformin excess such as gastrointestinal upset or lactic acidosis. Reduce the metformin dose if renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin-repaglinide
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Metformin-repaglinide?
MediHelp rates the interaction as moderate. Dofetilide and Metformin-repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dofetilide and metformin are both cationic drugs handled by renal tubular secretion, so they may compete for elimination. This could raise metformin concentrations, but the clinical significance is modest.
How serious is the interaction between Dofetilide and Metformin-repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin excess such as gastrointestinal upset or lactic acidosis. Reduce the metformin dose if renal function is impaired.
What other medicines interact with Metformin-repaglinide?
MediHelp also lists interactions of Metformin-repaglinide with, for example, Gemfibrozil, Apalutamide, Clarithromycin. The full list is on the Metformin-repaglinide page.
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