Drug interactions
Dofetilide + Sorafenib
Severity: Major
Dofetilide and Sorafenib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dofetilide has a narrow therapeutic index and causes dose-related QT prolongation and torsades de pointes. Adding sorafenib, which also prolongs the QT interval, increases that risk.
What this interaction means in plain words
Dofetilide and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid the combination and choose another antiarrhythmic or antineoplastic option. If it cannot be avoided, monitor the ECG closely and keep potassium and magnesium normal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sorafenib
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Sorafenib?
MediHelp rates the interaction as major. Dofetilide and Sorafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dofetilide has a narrow therapeutic index and causes dose-related QT prolongation and torsades de pointes. Adding sorafenib, which also prolongs the QT interval, increases that risk.
How serious is the interaction between Dofetilide and Sorafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and choose another antiarrhythmic or antineoplastic option. If it cannot be avoided, monitor the ECG closely and keep potassium and magnesium normal.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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