Drug interactions
Dofetilide + Sunitinib
Severity: Major
Dofetilide and Sunitinib: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lengthen the QT interval, and dofetilide carries a substantial intrinsic risk of torsades de pointes. Adding sunitinib increases the chance of serious ventricular arrhythmia.
What this interaction means in plain words
Dofetilide and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dofetilide belongs to Cardiovascular; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation (dofetilide blocks IKr; sunitinib has QT-prolonging effects).
What to do
Avoid concurrent use and select an alternative antiarrhythmic or antineoplastic if feasible. If both are essential, monitor ECG closely and maintain normal potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Dofetilide
- Amiodarone + Dofetilide Contraindicated
- Amisulpride + Dofetilide Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Dofetilide Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Candesartan-hydrochlorothiazide + Dofetilide Contraindicated
- Captopril-hydrochlorothiazide + Dofetilide Contraindicated
Frequently asked questions
Can I take Dofetilide with Sunitinib?
MediHelp rates the interaction as major. Dofetilide and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents can lengthen the QT interval, and dofetilide carries a substantial intrinsic risk of torsades de pointes. Adding sunitinib increases the chance of serious ventricular arrhythmia.
How serious is the interaction between Dofetilide and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and select an alternative antiarrhythmic or antineoplastic if feasible. If both are essential, monitor ECG closely and maintain normal potassium and magnesium.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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