Drug interactions
Dolasetron + Eliglustat
Severity: Major
Dolasetron and Eliglustat: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and eliglustat is itself contraindicated or restricted with some QT-prolonging antiarrhythmics. Combined use raises the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Dolasetron and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Eliglustat belongs to Miscellaneous.
Why it happens
Additive QT prolongation; eliglustat increases ECG intervals at high plasma concentrations.
What to do
Avoid if possible, particularly in poor CYP2D6 metabolizers or with CYP2D6/3A inhibitors. If used together, obtain baseline and follow-up ECGs and correct electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Dolasetron with Eliglustat?
MediHelp rates the interaction as major. Dolasetron and Eliglustat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and eliglustat is itself contraindicated or restricted with some QT-prolonging antiarrhythmics. Combined use raises the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Dolasetron and Eliglustat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, particularly in poor CYP2D6 metabolizers or with CYP2D6/3A inhibitors. If used together, obtain baseline and follow-up ECGs and correct electrolytes.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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