Drug interactions
Dolasetron + Fluvoxamine
Severity: Moderate
Dolasetron and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been reported rarely with 5-HT3 antagonists given with SSRIs. Fluvoxamine inhibits several CYP enzymes and could raise hydrodolasetron exposure.
What this interaction means in plain words
Dolasetron and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Fluvoxamine belongs to Central Nervous System.
Why it happens
Possible additive serotonergic effects and CYP inhibition by fluvoxamine that may increase hydrodolasetron levels.
What to do
Monitor for serotonin toxicity and QT-related symptoms. Consider an alternative antiemetic if cardiac risk is elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Frequently asked questions
Can I take Dolasetron with Fluvoxamine?
MediHelp rates the interaction as moderate. Dolasetron and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin syndrome has been reported rarely with 5-HT3 antagonists given with SSRIs. Fluvoxamine inhibits several CYP enzymes and could raise hydrodolasetron exposure.
How serious is the interaction between Dolasetron and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for serotonin toxicity and QT-related symptoms. Consider an alternative antiemetic if cardiac risk is elevated.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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