Drug interactions
Dolasetron + Granisetron
Severity: Moderate
Dolasetron and Granisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are 5-HT3 antagonists that can prolong the QT interval, and dolasetron is the more potent in this regard. Using two agents of this class together offers little added antiemetic benefit and increases arrhythmia risk.
What this interaction means in plain words
Dolasetron and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Granisetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation from class effects on cardiac repolarization.
What to do
Avoid duplicate 5-HT3 antagonist therapy and use one agent with a different class for breakthrough nausea. If both are given, monitor ECG and electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Granisetron
- Apomorphine + Granisetron Contraindicated
- Amiodarone + Granisetron Major
- Amisulpride + Granisetron Major
- Arsenic trioxide + Granisetron Major
- Artemether / lumefantrine + Granisetron Major
- Artemether + Granisetron Major
Frequently asked questions
Can I take Dolasetron with Granisetron?
MediHelp rates the interaction as moderate. Dolasetron and Granisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are 5-HT3 antagonists that can prolong the QT interval, and dolasetron is the more potent in this regard. Using two agents of this class together offers little added antiemetic benefit and increases arrhythmia risk.
How serious is the interaction between Dolasetron and Granisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid duplicate 5-HT3 antagonist therapy and use one agent with a different class for breakthrough nausea. If both are given, monitor ECG and electrolytes.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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