Drug interactions
Dolasetron + Hydroxyzine
Severity: Moderate
Dolasetron and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so giving them together may add to the risk of ventricular arrhythmia, including torsades de pointes. The risk is higher with electrolyte disturbances, heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Dolasetron and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Hydroxyzine belongs to Respiratory.
Why it happens
Additive prolongation of cardiac repolarization through blockade of cardiac potassium channels.
What to do
Obtain a baseline ECG and correct potassium and magnesium before use. Consider a non-QT-prolonging antiemetic if the patient has other risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Dolasetron with Hydroxyzine?
MediHelp rates the interaction as moderate. Dolasetron and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so giving them together may add to the risk of ventricular arrhythmia, including torsades de pointes. The risk is higher with electrolyte disturbances, heart disease or other QT-prolonging drugs.
How serious is the interaction between Dolasetron and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before use. Consider a non-QT-prolonging antiemetic if the patient has other risk factors.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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