Drug interactions
Dolasetron + Itraconazole
Severity: Moderate
Dolasetron and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole is associated with QT prolongation, and dolasetron's active metabolite also lengthens the QT and PR intervals. Together they may raise the likelihood of serious arrhythmia, especially in patients with cardiac disease or electrolyte abnormalities.
What this interaction means in plain words
Dolasetron and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Itraconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation; itraconazole inhibition of CYP3A4 may also modestly raise exposure to the dolasetron metabolite.
What to do
Check ECG and correct potassium and magnesium before starting. Choose an antiemetic without QT effect, such as a corticosteroid, in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Dolasetron with Itraconazole?
MediHelp rates the interaction as moderate. Dolasetron and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole is associated with QT prolongation, and dolasetron's active metabolite also lengthens the QT and PR intervals. Together they may raise the likelihood of serious arrhythmia, especially in patients with cardiac disease or electrolyte abnormalities.
How serious is the interaction between Dolasetron and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and correct potassium and magnesium before starting. Choose an antiemetic without QT effect, such as a corticosteroid, in high-risk patients.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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