Drug interactions
Dolasetron + Levomilnacipran
Severity: Moderate
Dolasetron and Levomilnacipran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levomilnacipran increases serotonergic and noradrenergic activity, and 5-HT3 antagonists such as dolasetron have been linked to serotonin syndrome when combined with serotonergic drugs. The risk is considered low but the reaction can be serious.
What this interaction means in plain words
Dolasetron and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Levomilnacipran belongs to Central Nervous System.
Why it happens
Additive serotonergic effects.
What to do
Monitor for agitation, tremor, hyperthermia, diarrhea and clonus, especially after dose changes. Stop one agent if serotonin toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Levomilnacipran
- Isocarboxazid + Levomilnacipran Contraindicated
- Levomilnacipran + Linezolid Contraindicated
- Levomilnacipran + Methylthioninium chloride Contraindicated
- Levomilnacipran + Phenelzine Contraindicated
- Levomilnacipran + Procarbazine Contraindicated
- Levomilnacipran + Rasagiline Contraindicated
Frequently asked questions
Can I take Dolasetron with Levomilnacipran?
MediHelp rates the interaction as moderate. Dolasetron and Levomilnacipran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levomilnacipran increases serotonergic and noradrenergic activity, and 5-HT3 antagonists such as dolasetron have been linked to serotonin syndrome when combined with serotonergic drugs. The risk is considered low but the reaction can be serious.
How serious is the interaction between Dolasetron and Levomilnacipran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, hyperthermia, diarrhea and clonus, especially after dose changes. Stop one agent if serotonin toxicity is suspected.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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