Drug interactions
Dolasetron + Osilodrostat
Severity: Moderate
Dolasetron and Osilodrostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osilodrostat can prolong the QT interval, and dolasetron has similar effects. Used together, they may raise the risk of torsades de pointes, particularly with hypokalemia or hypomagnesemia.
What this interaction means in plain words
Dolasetron and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Osilodrostat belongs to Endocrine.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG and correct electrolytes before and during treatment. Choose an antiemetic with less QT effect if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Dolasetron with Osilodrostat?
MediHelp rates the interaction as moderate. Dolasetron and Osilodrostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osilodrostat can prolong the QT interval, and dolasetron has similar effects. Used together, they may raise the risk of torsades de pointes, particularly with hypokalemia or hypomagnesemia.
How serious is the interaction between Dolasetron and Osilodrostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and correct electrolytes before and during treatment. Choose an antiemetic with less QT effect if possible.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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