Drug interactions
Dolasetron + Osimertinib
Severity: Moderate
Dolasetron and Osimertinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Osimertinib can prolong the QT interval and dolasetron has a similar effect. Their combination may increase the risk of ventricular arrhythmia, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Dolasetron and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Osimertinib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Obtain periodic ECG and electrolyte monitoring and correct abnormalities. Consider an alternative antiemetic if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Dolasetron with Osimertinib?
MediHelp rates the interaction as moderate. Dolasetron and Osimertinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Osimertinib can prolong the QT interval and dolasetron has a similar effect. Their combination may increase the risk of ventricular arrhythmia, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Dolasetron and Osimertinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain periodic ECG and electrolyte monitoring and correct abnormalities. Consider an alternative antiemetic if QT risk is high.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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