Drug interactions
Dolasetron + Rilpivirine
Severity: Moderate
Dolasetron and Rilpivirine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rilpivirine causes dose-related QT prolongation at supratherapeutic doses, and dolasetron prolongs the QT interval. Together they may increase the risk of torsades de pointes in patients with other risk factors.
What this interaction means in plain words
Dolasetron and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Rilpivirine belongs to Anti Virals.
Why it happens
Additive QT interval prolongation.
What to do
Monitor ECG in patients with cardiac risk factors and correct electrolytes. Prefer an alternative antiemetic if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Rilpivirine
- Carbamazepine + Rilpivirine Contraindicated
- Dexamethasone + Rilpivirine Contraindicated
- Dexlansoprazole + Rilpivirine Contraindicated
- Efavirenz + Rilpivirine Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Esomeprazole + Rilpivirine Contraindicated
Frequently asked questions
Can I take Dolasetron with Rilpivirine?
MediHelp rates the interaction as moderate. Dolasetron and Rilpivirine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rilpivirine causes dose-related QT prolongation at supratherapeutic doses, and dolasetron prolongs the QT interval. Together they may increase the risk of torsades de pointes in patients with other risk factors.
How serious is the interaction between Dolasetron and Rilpivirine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac risk factors and correct electrolytes. Prefer an alternative antiemetic if QT risk is high.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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