Drug interactions
Dolasetron + Solifenacin
Severity: Moderate
Dolasetron and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Solifenacin has been associated with dose-related QT prolongation, and dolasetron adds to cardiac conduction effects. The combination may modestly raise arrhythmia risk in vulnerable patients.
What this interaction means in plain words
Dolasetron and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Monitor ECG in patients with cardiac disease or electrolyte abnormalities, and keep solifenacin at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Solifenacin
Frequently asked questions
Can I take Dolasetron with Solifenacin?
MediHelp rates the interaction as moderate. Dolasetron and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Solifenacin has been associated with dose-related QT prolongation, and dolasetron adds to cardiac conduction effects. The combination may modestly raise arrhythmia risk in vulnerable patients.
How serious is the interaction between Dolasetron and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG in patients with cardiac disease or electrolyte abnormalities, and keep solifenacin at the lowest effective dose.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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