Drug interactions
Dolasetron + Vemurafenib
Severity: Major
Dolasetron and Vemurafenib: major interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib can cause concentration-dependent QT prolongation, and dolasetron also lengthens QTc. Combined use raises the risk of torsades de pointes.
What this interaction means in plain words
Dolasetron and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolasetron belongs to Gastrointestinal Tract; Vemurafenib belongs to Oncology.
Why it happens
Additive QT interval prolongation.
What to do
Avoid if possible and choose a non-QT-prolonging antiemetic. If used, monitor ECG and correct potassium, magnesium and calcium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Vemurafenib
Frequently asked questions
Can I take Dolasetron with Vemurafenib?
MediHelp rates the interaction as major. Dolasetron and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Vemurafenib can cause concentration-dependent QT prolongation, and dolasetron also lengthens QTc. Combined use raises the risk of torsades de pointes.
How serious is the interaction between Dolasetron and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and choose a non-QT-prolonging antiemetic. If used, monitor ECG and correct potassium, magnesium and calcium.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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