Drug interactions
Dolasetron + Vorinostat
Severity: Moderate
Dolasetron and Vorinostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vorinostat has been associated with QT prolongation and dolasetron prolongs QT in a dose-related way. The combination may add to arrhythmia risk, which is higher with electrolyte abnormalities common in oncology patients.
What this interaction means in plain words
Dolasetron and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Vorinostat belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization.
What to do
Correct hypokalemia and hypomagnesemia before and during therapy and monitor the ECG in patients with cardiac risk factors. Prefer a 5-HT3 antagonist with less QT effect or a different antiemetic class.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Dolasetron with Vorinostat?
MediHelp rates the interaction as moderate. Dolasetron and Vorinostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vorinostat has been associated with QT prolongation and dolasetron prolongs QT in a dose-related way. The combination may add to arrhythmia risk, which is higher with electrolyte abnormalities common in oncology patients.
How serious is the interaction between Dolasetron and Vorinostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia before and during therapy and monitor the ECG in patients with cardiac risk factors. Prefer a 5-HT3 antagonist with less QT effect or a different antiemetic class.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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