Drug interactions
Dolasetron + Zolmitriptan
Severity: Moderate
Dolasetron and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rare serotonin syndrome has been reported when triptans are combined with 5-HT3 antagonists. Zolmitriptan is typically used intermittently, so exposure overlap is limited.
What this interaction means in plain words
Dolasetron and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolasetron belongs to Gastrointestinal Tract; Zolmitriptan belongs to Central Nervous System.
Why it happens
Possible additive serotonergic activity; the mechanism is largely theoretical.
What to do
Counsel the patient on serotonin syndrome symptoms and monitor after co-administration. Discontinue both agents if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Dolasetron with Zolmitriptan?
MediHelp rates the interaction as moderate. Dolasetron and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rare serotonin syndrome has been reported when triptans are combined with 5-HT3 antagonists. Zolmitriptan is typically used intermittently, so exposure overlap is limited.
How serious is the interaction between Dolasetron and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel the patient on serotonin syndrome symptoms and monitor after co-administration. Discontinue both agents if symptoms occur.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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