Drug interactions
Dolutegravir + Etravirine
Severity: Major
Dolutegravir and Etravirine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Etravirine lowers dolutegravir concentrations substantially when given without a boosted protease inhibitor. This may lead to reduced viral suppression and resistance.
What this interaction means in plain words
Dolutegravir and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dolutegravir belongs to Anti Virals; Etravirine belongs to Anti Virals.
Why it happens
Etravirine induces UGT1A1 and CYP3A4, increasing dolutegravir clearance.
What to do
Use etravirine with dolutegravir only alongside atazanavir/ritonavir, darunavir/ritonavir or lopinavir/ritonavir; otherwise choose an alternative regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dolutegravir
Other interactions of Etravirine
- Efavirenz + Etravirine Contraindicated
- Etravirine + Isavuconazole Contraindicated
- Amobarbital + Etravirine Major
- Apalutamide + Etravirine Major
- Carbamazepine + Etravirine Major
- Cobicistat + Etravirine Major
Frequently asked questions
Can I take Dolutegravir with Etravirine?
MediHelp rates the interaction as major. Dolutegravir and Etravirine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Etravirine lowers dolutegravir concentrations substantially when given without a boosted protease inhibitor. This may lead to reduced viral suppression and resistance.
How serious is the interaction between Dolutegravir and Etravirine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use etravirine with dolutegravir only alongside atazanavir/ritonavir, darunavir/ritonavir or lopinavir/ritonavir; otherwise choose an alternative regimen.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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