Drug interactions
Dolutegravir + Tipranavir
Severity: Moderate
Dolutegravir and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted tipranavir lowers dolutegravir concentrations through enzyme induction. Reduced exposure may compromise HIV suppression.
What this interaction means in plain words
Dolutegravir and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dolutegravir belongs to Anti Virals; Tipranavir belongs to Anti Virals.
Why it happens
Induction of UGT1A1 and CYP3A4 by tipranavir/ritonavir increases dolutegravir metabolism.
What to do
Give dolutegravir 50 mg twice daily when used with tipranavir/ritonavir in patients without integrase resistance. Monitor viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolutegravir
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Dolutegravir with Tipranavir?
MediHelp rates the interaction as moderate. Dolutegravir and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir-boosted tipranavir lowers dolutegravir concentrations through enzyme induction. Reduced exposure may compromise HIV suppression.
How serious is the interaction between Dolutegravir and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dolutegravir 50 mg twice daily when used with tipranavir/ritonavir in patients without integrase resistance. Monitor viral load.
What other medicines interact with Dolutegravir?
MediHelp also lists interactions of Dolutegravir with, for example, Dofetilide, Aluminum hydroxide, Atidarsagene autotemcel. The full list is on the Dolutegravir page.
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