Drug interactions
Dopamine + Iloperidone
Severity: Moderate
Dopamine and Iloperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Iloperidone blocks dopamine D2 and alpha-1 adrenergic receptors, which can oppose the pressor and renal-vasodilating actions of dopamine. Alpha-1 blockade may also add to hypotension in a patient who is hemodynamically unstable. The result is an unpredictable and often reduced response to dopamine.
What this interaction means in plain words
Dopamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Iloperidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism at dopamine and alpha-1 adrenergic receptors.
What to do
Monitor blood pressure and urine output closely and titrate dopamine to effect; consider norepinephrine if the pressor response is inadequate. Hold iloperidone during acute shock where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Iloperidone
- Iloperidone + Thioridazine Contraindicated
- Alfuzosin + Iloperidone Major
- Amiodarone + Iloperidone Major
- Amisulpride + Iloperidone Major
- Amitriptyline + Iloperidone Major
- Anagrelide + Iloperidone Major
Frequently asked questions
Can I take Dopamine with Iloperidone?
MediHelp rates the interaction as moderate. Dopamine and Iloperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Iloperidone blocks dopamine D2 and alpha-1 adrenergic receptors, which can oppose the pressor and renal-vasodilating actions of dopamine. Alpha-1 blockade may also add to hypotension in a patient who is hemodynamically unstable. The result is an unpredictable and often reduced response to dopamine.
How serious is the interaction between Dopamine and Iloperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and urine output closely and titrate dopamine to effect; consider norepinephrine if the pressor response is inadequate. Hold iloperidone during acute shock where possible.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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