Drug interactions
Dopamine + Phentermine
Severity: Moderate
Dopamine and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic amine, and giving it with intravenous dopamine can produce additive increases in blood pressure and heart rate. This may provoke hypertension or tachyarrhythmia, especially in patients with underlying heart disease.
What this interaction means in plain words
Dopamine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dopamine belongs to Cardiovascular; Phentermine belongs to Central Nervous System.
Why it happens
Additive sympathomimetic effects through phentermine-induced catecholamine release and direct dopamine receptor and adrenergic agonism.
What to do
Monitor blood pressure, heart rate and rhythm closely during dopamine infusion and adjust the infusion rate accordingly. Consider withholding phentermine while the patient requires vasopressor support.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dopamine
- Dihydroergotamine intranasal + Dopamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dopamine + Promethazine Contraindicated
- Dopamine + Selegiline transdermal Contraindicated
- Amitriptyline + Dopamine Major
- Clomipramine + Dopamine Major
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Dopamine with Phentermine?
MediHelp rates the interaction as moderate. Dopamine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine is a sympathomimetic amine, and giving it with intravenous dopamine can produce additive increases in blood pressure and heart rate. This may provoke hypertension or tachyarrhythmia, especially in patients with underlying heart disease.
How serious is the interaction between Dopamine and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and rhythm closely during dopamine infusion and adjust the infusion rate accordingly. Consider withholding phentermine while the patient requires vasopressor support.
What other medicines interact with Dopamine?
MediHelp also lists interactions of Dopamine with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Promethazine. The full list is on the Dopamine page.
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