Drug interactions
Doxepin + Metoclopramide
Severity: Moderate
Doxepin and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant and metoclopramide is a dopamine antagonist, so the combination may increase sedation and extrapyramidal effects. Doxepin is also a CYP2D6 substrate with some inhibitory activity and has serotonergic and anticholinergic effects that may oppose prokinetic action.
What this interaction means in plain words
Doxepin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive CNS depression and dopamine blockade, with anticholinergic antagonism of metoclopramide's prokinetic action.
What to do
Monitor for sedation, extrapyramidal symptoms and serotonin toxicity features. Use the lowest effective doses and limit duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Metoclopramide?
MediHelp rates the interaction as moderate. Doxepin and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant and metoclopramide is a dopamine antagonist, so the combination may increase sedation and extrapyramidal effects. Doxepin is also a CYP2D6 substrate with some inhibitory activity and has serotonergic and anticholinergic effects that may oppose prokinetic action.
How serious is the interaction between Doxepin and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, extrapyramidal symptoms and serotonin toxicity features. Use the lowest effective doses and limit duration.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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