Drug interactions
Doxepin + Propofol
Severity: Moderate
Doxepin and Propofol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong antihistaminic activity, and it may add to the sedative effect of propofol. Additive hypotension and anticholinergic effects can also occur.
What this interaction means in plain words
Doxepin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxepin belongs to Dermatology; Propofol belongs to Central Nervous System.
Why it happens
Additive CNS depression from H1 antagonism by doxepin and GABA-A potentiation by propofol.
What to do
Titrate propofol to effect and monitor sedation depth, blood pressure and ECG. Reduce the dose in older or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Propofol
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Doxepin with Propofol?
MediHelp rates the interaction as moderate. Doxepin and Propofol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong antihistaminic activity, and it may add to the sedative effect of propofol. Additive hypotension and anticholinergic effects can also occur.
How serious is the interaction between Doxepin and Propofol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate propofol to effect and monitor sedation depth, blood pressure and ECG. Reduce the dose in older or frail patients.
What other medicines interact with Propofol?
MediHelp also lists interactions of Propofol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Propofol page.
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