Drug interactions
Doxycycline + Pacritinib
Severity: Minor
Doxycycline and Pacritinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized mainly by CYP3A4 and can prolong the QT interval and cause bleeding and diarrhea. Doxycycline is not an established CYP3A4 inhibitor, so a significant increase in exposure is unlikely.
What this interaction means in plain words
Doxycycline and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Doxycycline belongs to Anti Bacterial; Pacritinib belongs to Oncology.
Why it happens
Theoretical weak CYP3A4 inhibition by doxycycline; not demonstrated.
What to do
No dose change is needed; monitor ECG and for bleeding as usual for pacritinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Doxycycline with Pacritinib?
MediHelp rates the interaction as minor. Doxycycline and Pacritinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pacritinib is metabolized mainly by CYP3A4 and can prolong the QT interval and cause bleeding and diarrhea. Doxycycline is not an established CYP3A4 inhibitor, so a significant increase in exposure is unlikely.
How serious is the interaction between Doxycycline and Pacritinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor ECG and for bleeding as usual for pacritinib.
What other medicines interact with Doxycycline?
MediHelp also lists interactions of Doxycycline with, for example, Acitretin, Aminolevulinic acid, Cholera vaccine. The full list is on the Doxycycline page.
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