Drug interactions
Doxycycline + Sucralfate
Severity: Moderate
Doxycycline and Sucralfate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sucralfate can bind oral doxycycline in the gut, lowering its absorption and possibly reducing antibacterial effect. The impact is less than with older tetracyclines but is still plausible, especially when doses are taken together.
What this interaction means in plain words
Doxycycline and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Doxycycline belongs to Anti Bacterial; Sucralfate belongs to Gastrointestinal Tract.
Why it happens
Aluminum-containing sucralfate binds or chelates doxycycline in the gastrointestinal tract, reducing absorption.
What to do
Give doxycycline at least 2 hours before sucralfate. Watch for treatment failure in serious infections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sucralfate
Other interactions of Doxycycline
- Acitretin + Doxycycline Contraindicated
- Aminolevulinic acid + Doxycycline Major
- Cholera vaccine + Doxycycline Major
- Doxycycline + Isotretinoin Major
- Doxycycline + Methoxyflurane Major
- Doxycycline + Microbiota Major
Frequently asked questions
Can I take Doxycycline with Sucralfate?
MediHelp rates the interaction as moderate. Doxycycline and Sucralfate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sucralfate can bind oral doxycycline in the gut, lowering its absorption and possibly reducing antibacterial effect. The impact is less than with older tetracyclines but is still plausible, especially when doses are taken together.
How serious is the interaction between Doxycycline and Sucralfate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give doxycycline at least 2 hours before sucralfate. Watch for treatment failure in serious infections.
What other medicines interact with Sucralfate?
MediHelp also lists interactions of Sucralfate with, for example, Ciprofloxacin, Gemifloxacin, Levofloxacin. The full list is on the Sucralfate page.
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