Drug interactions
Dronabinol + Fluconazole
Severity: Moderate
Dronabinol and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is metabolized by CYP2C9 and CYP3A4, both inhibited by fluconazole. Higher dronabinol levels may increase psychoactive effects such as drowsiness, dizziness, anxiety and tachycardia.
What this interaction means in plain words
Dronabinol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Fluconazole inhibits CYP2C9 and CYP3A4, decreasing dronabinol metabolism.
What to do
Monitor for excessive sedation, mood changes and tachycardia. Reduce the dronabinol dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Fluconazole?
MediHelp rates the interaction as moderate. Dronabinol and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronabinol is metabolized by CYP2C9 and CYP3A4, both inhibited by fluconazole. Higher dronabinol levels may increase psychoactive effects such as drowsiness, dizziness, anxiety and tachycardia.
How serious is the interaction between Dronabinol and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation, mood changes and tachycardia. Reduce the dronabinol dose if adverse effects occur.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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