Drug interactions
Dronabinol + Gemfibrozil
Severity: Moderate
Dronabinol and Gemfibrozil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dronabinol is metabolized mainly by CYP2C9 and CYP3A4. Gemfibrozil inhibits CYP2C9 to some extent, so dronabinol exposure may rise, increasing cannabinoid effects such as dizziness, sedation, tachycardia and mood changes.
What this interaction means in plain words
Dronabinol and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Gemfibrozil belongs to Cardiovascular.
Why it happens
Gemfibrozil inhibition of CYP2C9-mediated dronabinol metabolism, predicted from in vitro data and enzyme involvement.
What to do
Monitor for increased psychoactive and cardiovascular effects when gemfibrozil is added to dronabinol. Reduce the dronabinol dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Gemfibrozil
- Daprodustat + Gemfibrozil Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Gemfibrozil + Mavacamten Contraindicated
- Gemfibrozil + Metformin-repaglinide Contraindicated
- Gemfibrozil + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Gemfibrozil + Repaglinide Contraindicated
Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Frequently asked questions
Can I take Dronabinol with Gemfibrozil?
MediHelp rates the interaction as moderate. Dronabinol and Gemfibrozil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dronabinol is metabolized mainly by CYP2C9 and CYP3A4. Gemfibrozil inhibits CYP2C9 to some extent, so dronabinol exposure may rise, increasing cannabinoid effects such as dizziness, sedation, tachycardia and mood changes.
How serious is the interaction between Dronabinol and Gemfibrozil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased psychoactive and cardiovascular effects when gemfibrozil is added to dronabinol. Reduce the dronabinol dose if adverse effects occur.
What other medicines interact with Gemfibrozil?
MediHelp also lists interactions of Gemfibrozil with, for example, Daprodustat, Elagolix, Mavacamten. The full list is on the Gemfibrozil page.
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