Drug interactions
Dronabinol + Levoketoconazole
Severity: Moderate
Dronabinol and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and also inhibits CYP2C9, the main pathways for dronabinol metabolism. Dronabinol exposure may increase substantially, with more intense psychoactive, sedative and cardiovascular effects.
What this interaction means in plain words
Dronabinol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Levoketoconazole belongs to Endocrine.
Why it happens
Levoketoconazole inhibits CYP3A4 and CYP2C9, reducing dronabinol clearance.
What to do
Start dronabinol at a reduced dose and monitor for sedation, tachycardia, hypotension and mood changes. Adjust the dose according to tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dronabinol with Levoketoconazole?
MediHelp rates the interaction as moderate. Dronabinol and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole is a strong CYP3A4 inhibitor and also inhibits CYP2C9, the main pathways for dronabinol metabolism. Dronabinol exposure may increase substantially, with more intense psychoactive, sedative and cardiovascular effects.
How serious is the interaction between Dronabinol and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start dronabinol at a reduced dose and monitor for sedation, tachycardia, hypotension and mood changes. Adjust the dose according to tolerability.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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