Drug interactions
Dronabinol + Lopinavir
Severity: Moderate
Dronabinol and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lopinavir is co-formulated with ritonavir, a potent CYP3A4 inhibitor, which can raise dronabinol concentrations. This may increase sedation, dizziness, tachycardia and psychiatric effects.
What this interaction means in plain words
Dronabinol and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dronabinol belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
The ritonavir-boosted lopinavir regimen inhibits CYP3A4-mediated dronabinol metabolism.
What to do
Start with a low dronabinol dose and monitor for excess CNS and cardiovascular effects. Reduce the dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dronabinol
- Cefotetan + Dronabinol Contraindicated
- Disulfiram + Dronabinol Contraindicated
- Dronabinol + Midazolam intranasal Major
- Dronabinol + Zuranolone Major
- Amobarbital + Dronabinol Moderate
- Apalutamide + Dronabinol Moderate
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Dronabinol with Lopinavir?
MediHelp rates the interaction as moderate. Dronabinol and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lopinavir is co-formulated with ritonavir, a potent CYP3A4 inhibitor, which can raise dronabinol concentrations. This may increase sedation, dizziness, tachycardia and psychiatric effects.
How serious is the interaction between Dronabinol and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with a low dronabinol dose and monitor for excess CNS and cardiovascular effects. Reduce the dose if adverse effects occur.
What other medicines interact with Dronabinol?
MediHelp also lists interactions of Dronabinol with, for example, Cefotetan, Disulfiram, Midazolam intranasal. The full list is on the Dronabinol page.
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